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Definition of "protamine" []

  • Any of a group of simple proteins found in fish sperm that are strongly basic, are soluble in water, are not coagulated by heat, and yield chiefly arginine upon hydrolysis. In purified form, they are used in a long-acting formulation of insulin and to neutralize the anticoagulant effects of heparin. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

Use "protamine" in a sentence
  • "One test was normal, but the other two were given another drug, protamine sulfate, that reverses the effects of heparin."
  • "Langberg also said two patients were given protamine sulfate, a drug that reverses the effects of heparin."
  • "After two years in their laboratory, during which time I studied the interaction of protamine with rabbit muscle phosphorylase, I became so enamored with biochemistry that"