Definition of "diphosphonate" []

• Any compound (especially a class of drugs) having two phosphonate groups (noun)

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• "Since emerging evidence suggests that biomarkers of bone turnover carry notable potential to become useful tools for monitoring patients with metastatic bone disease, we measured a panel of bone formation and bone resorption markers in a relatively homogenous group of patients with hormone-refractory prostatic carcinoma (HRPC) and bone only metastases, immediately before 186Rhenium-l, l-hydroxyethylidene diphosphonate (186Re-HEDP) therapy and strictly after"