Definition of "bisphosphonate" [bisphosphonate]

• Any of a class of organic compounds having two phosphate groups attached to a single carbon atom (noun)
• Several pharmaceuticals, having this structure, that are used to treat Paget's disease by restricting bone loss (noun)

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• "However, as these new studies point out, more research is needed to clarify the effects of long-term bisphosphonate use on bone quality."
• "In conducting a review of the patients 'charts, the doctors found that the 63 patients, diagnosed with ONJ over a 3-year period, shared one commonality, they all had received long-term bisphosphonate therapy."
• ""Recent research suggests that suppressed bone remodeling from long-term bisphosphonate use might result in brittle bone that is prone to atypical fractures," said Gladnick."