To defriend; to remove from one's friends list (eg on a social networking website).(verb)
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Use "unfriend" in a sentence
"The contenders for 2009 Big Law Word of the Year are not as hip as Oxford's Word of the Year -- a nod to Facebook's influence, "unfriend" -- but who said Big Law was hip?"
"I think it's no coincidence, though, that to "unfriend" - essentially dropping a connection with someone made on Facebook - is the Oxford American Dictionary's 2009 Word of the Year as this decade of frenzied communication comes to a close."
"The New Oxford American Dictionary named "unfriend" -- as in deleting someone as a friend on a social network such as Facebook -- its word of the year on Monday."