Definition of "tophaceous" []

• Gritty; sandy; rough; stony (adjective)

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• "In tophaceous gout (which is marked by frequent recurrence), uric acid crystal deposits - called tophi - show up in the different tissues near the joints."
• "With allopurinol it has been possible to prevent and reduce in the tophaceous deposits and to prevent urate stone formation (74), (81), (87), (89,90)."
• ""With the dramatic reduction in serum uric acid observed when RDEA594 and febuxostat are administered in combination, together these agents may be able to produce reductions in tophaceous gout previously achieved only with intravenous therapy.""