Positioned facing another, with the toes touching(adjective)
Against, in opposition.(adjective)
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Use "toe-to-toe" in a sentence
"He had used his procedural mastery to humiliate them on the Senate floor, and they were afraid to go toe-to-toe with him."
"Could Thurman go toe-to-toe with Blackbeard and win?"
"Though she's gone toe-to-toe with Storybrooke's mayor Regina, who adopted Henry Jared Gilmore, the son Emma gave up for adoption 10 years ago, she'll have to face the ultimate antagonist of the story: Regina's fairytale counterpart, The Evil Queen."