Definition of "titration" [ti•tra•tion]

• The process, operation, or method of determining the concentration of a substance in solution by adding to it a standard reagent of known concentration in carefully measured amounts until a reaction of definite and known proportion is completed, as shown by a color change or by electrical measurement, and then calculating the unknown concentration. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "‡ The term titration is occasionally used informally to suggest extreme precision in some sort of measurement or determination."
• "Medical doctors use the term titration to describe the process of adjusting the standard dosage of a medication up or down based on an individual patient’s reactions."
• "Both of the pivotal clinical studies enrolled adult patients with moderate to severe chronic low back pain and included open-label titration periods followed by randomized, double-blind, 12-week study periods."