Definition of "thioguanine" []

• A derivative of guanine obtained by replacing the carbonyl group with a thiol; it is an antineoplastic agent (noun)

Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License

• "Our research was untargeted, and the line of inquiry we had begun in the 1940s yielded new drug therapies for malaria (pyrimethamine), leukemia (6-mercaptopurine and thioguanine), gout (allopurinol), organ transplantation"
• "Stimulated by this finding Elion and Hitchings continued their research which soon resulted in two new chemotherapeutic drugs, thioguanine (1950) and"
• "Meanwhile, the pursuit of 6-MP, thioguanine, azathioprine and allopurinol had occupied 20 years."