Definition of "thiazolidinedione" [thiazolidinedione]

• Any of a class of drugs, used to treat diabetes, containing a five-membered heterocyclic ring containing a nitrogen and a sulfur atom and two carbonyl groups. (noun)

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• "Another recent study suggests that diabetics who are being treated with thiazolidinedione, an antidiabetic drug, provided “further evidence of a possible association between long-term use of thiazolidinediones and fractures, particularly of the hip and wrist, in patients with diabetes mellitus.”"
• "On December 12, 2007, JAMA reported another population-based study by Canadian researchers of patients 66 and older with diabetes, that found thiazolidinedione treatment, primarily with Avandia, was associated with an increased risk of congestive heart failure, acute myocardial infarction, and mortality when compared with other combination oral hypoglycemic agent treatments."
• "The Committee points out that Dr Buse is an expert in diabetes with extensive research experience in the thiazolidinedione class of drugs that includes Avandia and states: "Corporate intimidation, the silencing of scientific dissent, and the suppression of scientific views threaten both the public well-being and the financial health of the federal government, which pays for health care.""