Definition of "secretase" []

• An enzyme that "snips" pieces off a longer protein that is embedded in the cell membrane. (noun)

Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License

• "Lilly's semagacestat aimed to slow or reverse the progression of Alzheimer's disease by inhibiting an enzyme called gamma secretase, which is important in building a sticky substance called amyloid that can clump in the brain."
• "Lilly's drug was designed to reduce the body's production of the plaques by inhibiting the activity of an enzyme, called gamma secretase, that is believed to play an important role in formation of the plaque."
• "The mutations affect a protein called gamma-secretase, which is involved in the build-up of protein plaques in the brains of people"