Definition of "screw up" [screw up]

• To tighten or secure with screws. (verb)
• To raise (rent, fees, etc.) to extortionate levels. (verb)
• To twist into a contorted state (verb)
• To make a mess of; to ruin. (verb)
• To blunder; to make a mistake. (verb)

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• "But Taylor Lockwood did not screw up and a cursory review of her ball-busting work on the case over the past weeks revealed no glitches the remedy for which would involve her summarily getting kicked off the deal."
• "Anticholinergics block the action of acetylcholine at the synapse and screw up nervous transmission."
• "Somehow Ben managed simultaneously to screw up his face in distaste at the memory and masticate energetically."