Superlative form of safe: most safe, most safe.(adjective)
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Use "safest" in a sentence
"Recently, Mayor Michael Bloomberg announced the latest crime statistics for New York City, numbers that capped what he called the "safest decade in recorded city history.""
"At the same time, most women will tell you the one security blanket that would make them feel safest is knowing they would always have a home to live in."
"On my watch as police chief in San Jose, the city was named the safest large city in the country, despite having the fewest police per capita."