Definition of "proteasomal" []

• Of or pertaining to a proteasome (adjective)

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• "A recent report demonstrated that RACK1 protein promotes ubiquitination of HIF-1α induced by the HSP90 inhibitor 17-AAG and its subsequent VHL-independent proteasomal degradation competing with HSP90 for binding to PAS domain of HIF-1α"
• "By dissecting the molecular mechanism of this process, we found that bcl-2 increases HIF-1α protein stability through the involvement of the molecular chaperone HSP90, which was found to protect HIF-1α from proteasomal degradation, even in VHL-deficient cells"
• "In conclusion, our study establishes a molecular link and highlights the possibility that bcl-2 is a new HIF-1α-binding protein whose multivalent interactions are required for the stabilization of HIF-1α, and that nuclear localization of bcl-2 may have an important role in protecting HIF-1α from ubiquitination and proteasomal degradation that commences in the nucleus."