A spot characteristic of the plague or of some foul disease.(noun)
A spot or locality where the plague or other foul disease is prevalent.(noun)
The Century Dictionary (Public Domain)
Use "plague-spot" in a sentence
"It seemed as though the world were becoming ignited from that one plague-spot of fire."
"The pupil in the school possessing the happiest disposition was a young girl from the country, Louise Path; she was sufficiently benevolent and obliging, but not well taught nor well mannered; moreover, the plague-spot of dissimulation was in her also; honour and principle were unknown to her, she had scarcely heard their names."
"Besides that, it was easier, there being nothing to conceal; whereas, in referring to an earlier time, a certain name had to be shirked and gone round about, like a plague-spot."