Definition of "osteoprotegerin" [osteoprotegerin]

• A cytokine that can inhibit the production of osteoclasts. (noun)

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• "They studied a protein called osteoprotegerin (OPG), which in healthy people plays a crucial role in maintaining bone health by controlling the rate at which bone tissue is removed."
• "Chen Y, Stephens O, Brown N, Chen B, et al. (2008) Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma."
• "Bu G, Lu W, Liu CC, Selander K, Yoneda T, et al. (2008) Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases."