Definition of "orthotopic" [orthotopic]

• In the normal position (adjective)

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• "Ryckman FC, Flake AW, Fisher RA, Tchervenkov JI, Pedersen SH, Balistreri WF: Segmental orthotopic hepatic transplantation as a means to improve patient survival and diminish waiting list mortality."
• "Moore developed the surgical technique for orthotopic canine liver transplantation (43), the model procedure used by Starzl for first successful human liver allografts (44)."
• "- Design and execute in vivo animal xenograft tumor models, such as subcutaneous, orthotopic, metastasis."