Definition of "nonsynonymous" [nonsynonymous]

• Not synonymous (adjective)

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• "Four novel nonsynonymous mutations were detected, one of which would produce premature termination of translation c.2686CT p."
• "They measured the fitness effect of the mutations as a ratio between synonymous (Ks) and nonsynonymous (Ka) amino acid substitutions (so they sequenced 13 mitochondrial genes and counted substitutions)."
• "As a longtime sometime magician, I want to point out that distraction and misdirection are overlapping but nonsynonymous."