Definition of "neurosphere" [neurosphere]

• A free-floating structure generated in vitro by neural stem cells (noun)

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• "These results may suggest that most cells in the hNPs remain in the PNS precursor state while some intrinsic PNS differentiation is taking place at the periphery of the neurosphere."
• "The neurosphere transplants eventually grew into tumors and reignited the Notch pathway."
• "In agreement with this hypothesis, we find that Nolz1 over-expression promotes cell cycle exit of NPCs in neurosphere cultures and negatively regulates proliferation in telencephalic organotypic cultures."