Definition of "nephrotoxicity" [nephrotoxicity]

• The state or condition of being nephrotoxic. (noun)

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• "Transplant patients need to maintain a minimum blood level of tacrolimus for the prevention of transplant allograft rejection, but excessive levels may increase the risk of serious side effects such as nephrotoxicity and opportunistic infections."
• "At such low amounts, lithium is unlikely to produce the negative side effects -- hypothyroidism, nephrotoxicity, weight gain -- that complicate its use as a psychiatric drug."
• "Belatacept is different from calcineurin inhibitors (CNI), such as cyclosporine, which is the class of drugs most commonly used to suppress the immune system in transplant patients, because it does not cause the toxicities associated with CNI - such as nephrotoxicity and aggravating cardiovascular risk factors."