Definition of "metalloproteinase" [metalloproteinase]

• Any of several proteinases that have a metal atom (often zinc) at their active centre. (noun)

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• "The strongest AMD genetic association found in the study was in a region on chromosome 22, near a gene called metalloproteinase inhibitor 3 (TIMP3)."
• "Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts."
• "When transcription factors such as AP-1 are activated, they produce and release collagen-digesting proteins matrix metalloproteinase, resulting in microscarring in the deep portion of the skin called the dermis."