Definition of "megakaryocyte" []

• A large bone marrow cell with a lobulate nucleus that gives rise to blood platelets. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "Platelets are formed in the cytoplasm of a very large cell, the megakaryocyte."
• "The cytoplasm of the megakaryocyte fragments at the edge of the cell."
• "The condition also is characterized by proteolysis of platelet α-proteins such as platelet factor V and von Willebrand factor, further interfering with clot function, and with increased uPA messenger RNA levels, particularly during megakaryocyte differentiation."