The office that serves as the administrative center of an enterprise(noun)
Gnu Collaboartive International Dictionary of English: licensed under The Code Project Open License (CPOL)
Use "main office" in a sentence
"Fortunately, Mrs. Armstrong allows her to retreat strategically to the back of the room whenever confinement to a desk chair becomes unbearable for Meg. To help her meet the all-consuming need to discharge her surplus of physical energy, Meg is regularly assigned to run errands to the main office and other destinations."
"The main office secretary saw it was for a gay-straight alliance and said, ‘I think Mr. Arbuthnot will want to speak to you about this.’"
"The main office is equipped with all modern communication facilities, including telexes."