Definition of "lipofuscin" [lipofuscin]

• Any of a family of pigmented lipid granules that accumulates in several body tissues (noun)

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• "Normally activated by near-starvation, SIRT-1 extends life by, among other things, reducing the amount of intracellular junk (called lipofuscin) that accumulates from metabolism."
• "5 Miscellaneous free-radical reactions form residues called lipofuscin or age pigment."
• "With age, there may be insufficient digestion of damaged macromolecules and organelles by the RPE, which will lead to progressive accumulation of biological "garbage", such as lipofuscin, and release of partially digested or undigested materials."