Definition of "leukodystrophy" [leukodystrophy]

• Any of a group of disorders characterized by progressive degeneration of the white matter of the brain, caused by imperfect growth or development of the myelin sheath that acts as an insulator around nerve fibres. (noun)

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• "Gaucher disease; Niemann-Pick disease; Krabbe disease; metachromatic leukodystrophy; Tay Sachs; Sandhoff"
• "His three sons have a devastating metabolic disease called metachromatic leukodystrophy, or MLD."
• "The author created the character, Android, from a child born with a genetic anomaly called leukodystrophy."