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To rouse to impatience or anger; annoy: a loud bossy voice that irritates listeners. See Synonyms at annoy.
(verb-transitive)
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To chafe or inflame.
(verb-transitive)
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Physiology To cause physiological activity or response in (an organ or tissue), as by application of a stimulus.
(verb-transitive)
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To be a cause of impatience or anger.
(verb-intransitive)
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.