Definition of "inflammasome" [inflammasome]

• A multi-protein complex that is responsible for inflammatory rheumatic diseases via activation of caspases (noun)

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• "Nlrp3 works by anchoring a large, multi-protein complex known as the Nlrp3 inflammasome where the messenger protein interleukin 18 (IL-18) is made."
• "In this study, researchers showed IL-18 produced by the Nlrp3 inflammasome helped mice maintain healthy colon by triggering production of more epithelial cells to compensate for those damaged or destroyed by colitis."
• "The missing link: how the inflammasome senses oxidative stress"