Seriously; sincerely, in a significant manner; with considerable commitment, determination, or effect.(adverb)
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Use "in earnest" in a sentence
"Civil wars soon began in earnest when Perdiccas had Meleager murdered in the sanctuary of a temple where he had sought refuge."
"Her rise to mega-stardom began in earnest in 1995, when MTV hired her to co-host its new dating show, Singled Out."
"(As a matter of curiosity we may mention that there have been people who took in earnest the interpretation of prosa as = pro sã, i.e. pro sequentia.)"