Definition of "hypermethylation" [hypermethylation]

• An increase in the epigenetic methylation of cytosine and adenosine residues in DNA. (noun)

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• "The national research group discovered that hypermethylation is a defining aspect of secondary glioblastomas, malignancies that have progressed from lower-grade tumors."
• "They also found that of the 1,520 genes with promoter hypermethylation, only 293 genes, or"
• "Conclusions p16 hypermethylation is the principal mechanism of p16 protein underexpression and plays an important role in the ESCC development."