Definition of "homeodomain" [homeodomain]

• A folded protein domain that binds to DNA and has a function in transcription (noun)

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• "These are the Hox genes; they are recognizable by virtue of the presence of a 60 amino acid long DNA binding region called the homeodomain, by similarities in sequence, by their role as regulatory genes expressed early in development, by the restriction of their expression to bands of tissue, by their clustering in the genome to a single location, and by the remarkable collinearity of their organization on the chromosome to their pattern of expression: the order of the gene's position in the cluster is related to their region of expression along the length of the animal."
• "One possible candidate for such front-loaded ˜information 'would be the homeodomain proteins."
• "Subsequent work has shown that homeodomain helix-turn-helix motifs are somewhat different from bacterial ones Branden, C., and Tooze, J.1999."