Definition of "holoprosencephaly" [holoprosencephaly]

• A congenital disorder involving insufficient division of the lobes of the brain during fetal development, resulting in skull and facial deformities ranging from minor cleft lip problems to cyclopia, in which a single eye develops where the nose would normally be. (noun)

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• "This is a condition known as holoprosencephaly which is thought to be caused by a defective chromosome."
• "In 2006, a kitten born with one eye and no nose a rare condition called holoprosencephaly, created a stir online as news organizations and bloggers tried to determine if the bizarre photos of the animal were real."
• "St. Jude scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE)."