Definition of "hepcidin" [hepcidin]

• A hormone produced by the liver that regulates iron homeostasis in mammals. (noun)

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• "ALN-HPN is a new development program, comprising a systemic RNAi therapeutic targeting hepcidin, a genetically defined gene in iron homeostasis, for the treatment of refractory anemia."
• "In addition, our ALN-PCS program represents an opportunity in severe hypercholesterolemia for a novel therapeutic strategy that phenocopies human genetics, and our new program targeting hepcidin creates an opportunity for RNAi therapeutics in the treatment of refractory anemias."
• "Pre-clinical studies with a candidate ALN-HPN siRNA have demonstrated the ability to silence the hepcidin gene and increase serum iron levels."