Definition of "hepatotoxicity" [hepatotoxicity]

• The quality or condition of being toxic or destructive to the liver. (noun)
• The capacity of a substance to have damaging effects on the liver. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "Direct-acting pressors have their action extracellularly at postsynaptic receptors. 4 The evaluation of liver function at initial presentation andfour tosix weeks following recovery is recommended, although the incidence of hepatotoxicity following acute overdose is rare. 5 Caution should be exercised in the use of sedative/hypnotics for CNS excitation because of synergistic depressant effects during overdose."
• "Several patients have been described who survived severe CNS depression, only to suffer severe acetaminophen hepatotoxicity due to unrecognized toxic acetaminophen levels."
• "Other warnings include hepatotoxicity or liver damage, effects on blood pressure and bleeding."