Definition of "haploinsufficiency" [haploinsufficiency]

• The state of a diploid organism having only a single copy of a particular gene, the other copy being inactivated due to mutation (noun)

Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License

• "Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA, et al. (1999) Genomic profiling of drug sensitivities via induced haploinsufficiency."
• "If feedback regulation were predominant, transcription factor haploinsufficiency in humans would be less common."
• "In the presence of strong compensatory mechanism that maintain protein levels, drug-induced haploinsufficiency would still be observed due to saturation of feedback mechanisms."