A disease or disorder that is inherited genetically(noun)
WordNet. Princeton University. 2010.
Use "genetic defect" in a sentence
"If researchers are able to demonstrate that the same genetic defect found in the mouse model also creates susceptibility in human lupus, it might open ways to block the disease by developing new drugs that block the activation of a defective Ly108 gene."
"Since prolactin release is regulated in part by the dopaminergic system, and alcohol causes dopamine release, these differences in prolactin levels may indicate a genetic defect in the brain of sons of alcoholics that results in a predisposition toward alcohol-seeking behavior."