Definition of "geldanamycin" [geldanamycin]

• A particular benzoquinone ansamycin antibiotic (noun)

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• "Many pharmacological inhibitors of Hsp90 such as geldanamycin and 17-AAG target the amino-terminal ATP binding pocket of Hsp90, thereby inhibiting its chaperone function"
• "L (2006) Chaperoning oncogenes: Hsp90 as a target of geldanamycin."
• "Examples of each class include pertuzumab and trastuzumab (which block dimerization and suppress signaling by binding to extracellular domains II and IV, respectively); the HER2/neu TK-inhibitor lapatinib; and Hsp90 inhibitors including geldanamycin derivatives,"