Definition of "downregulation" [downregulation]

• The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity (noun)

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• "The logical first step, then, is to protect the cell before damage occurs, including the cell membrane, mitochondria, and DNA, as well as the downregulation of inflammatory genes."
• "As insulin loses function, more insulin is required, more insulin leads to more downregulation of receptors, all of which ultimately leads to obesity."
• "In gaining muscle mass, one of his recommendations is to “drop calories by 50% one day per week to prevent protein uptake downregulation.”"