Definition of "diphenhydramine" [diphenhydramine]

• An antihistamine and sedative drug that blocks the effect of histamine at H1 receptor sites, reducing smooth muscle contraction. (noun)

Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License

• "And the medicine known as diphenhydramine (found in many allergy medications and nighttime pain pills) has an “anticholinergic†effect; it blocks communication between nerve cells."
• "No. You write about diphenhydramine, which is indicated for allergies, motion sickness, insomnia, and mild cases of parkinsonism; Seroquel, which is for mental illness, and it is way more expensive than generic pain medications containing hydrocodone or tramadol;"
• "If the condition persists, your doctor may recommend either an antihistamine such as diphenhydramine (Benadryl Allergy) or doxepin cream (Zonalon); a nonsteroidal anti-inflammatory ointment or cream such as tacrolimus (Protopic); or a corticosteroid ointment such as hydrocortisone (Cortaid, Cortizone)."