To vary, as from a regular course; deviate: depart from custom. See Synonyms at swerve.(verb-intransitive)
To go away from; leave.(verb-transitive)
American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Use "depart" in a sentence
"All of a sudden, the oil companies were forced to depart from the strategy that had worked so well for them in the past."
"The stimulus package is expected to depart from the "dams and bridges" model favored by the Liberal Democratic Party during its nearly 60 years of post-World War II rule."
"We were given a script to learn and instructed not to depart from the script."