An effect that makes a game character weaker; a status effect.(noun)
Wiktionary.org : Text is available under the Creative Commons Attribution-ShareAlike License
Use "debuff" in a sentence
"Aimed Shot now has a Mortal Strike like debuff, meaning that a warrior is not the only option when needing to cut down the utility of an opposing teams healer."
"He just turned the damage to magic weapons and the like into a temporary “debuff”, basically."
"It confers no bonus on the owner beyond possible investment increase and actually gives a "-1 enjoyment" debuff to the Audience Guild."