Definition of "cox-1" []

• An enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys (noun)

WordNet. Princeton University. 2010.

• "But the risk was increased by 18 percent by NSAIDS that acted against cox-1, compared to a 60 percent increase for those with the greatest cox-2 activity."
• ""We found a significant correlation between the degree of inhibition in vitro [in the laboratory] of whole blood cox-2, but not whole blood cox-1," said the report by researchers in Spain and Italy."
• "A newer generation of NSAIDs that act against cox-2 reduce the gastrointestinal bleeding, pain and inflammation that are major side effects of the cox-1 drugs, but they have been found to increase the risk of heart attack and stroke."