To protect from intrusion by enclosing in a rope barrier.(verb)
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Use "cordon off" in a sentence
"I suggest that you take your Germans to the Atrium Vestae in the middle of the night, Caesar, and cordon off the whole area outside its lodgement doors."
"Lictors rushed to cordon off the area, the crowd was pushed elsewhere, and Spurius and Aulus Albinus stood looking down at a dead man and ruined plans."