Definition of "co-stimulation" []

• The requirement of T cells for two signals in order to become fully activated (noun)

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• "Food and Drug Administration´s (FDA) Cardiovascular and Renal Drugs Advisory Committee has voted 13 to 5 to recommend approval of belatacept, a selective co-stimulation blocker, for the prophylaxis of acute rejection in de novo kidney transplant patients."
• "Macrophages were treated with noscapine or brominated noscapine analogs at 10, 25 and 50 µM prior to stimulation or co-stimulation with highly purified TLR-ligands (meningococcal LPS, a TLR4-MD-2 ligand and the synthetic lipopetide Pam3CSK4, a TLR2 ligand)."
• "This study doesn't conclude that dual influence of IL-4 and TGF-β in presence of TCR stimulation and co-stimulation induces human"