Definition of "aphidicolin" []

• A tetracyclic diterpene antibiotic with antiviral and antimitotical properties. (noun)

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• "The cells are dividing, but the authors showed that proliferation is not necessary for elongation, in experiments with mitomycin C and aphidicolin."
• "Several studies have predicted that some CNV and nonrecurring copy number changes (CNC) in cancer cell lines, which are induced by aphidicolin or occur in some cases of Duchenne muscular dystrophy, Smith-Magenis syndrome, and Pelizaeus-Merzbacher disease, originate from nonhomologous end joining, fork stalling and template switching, or microhomology/microsatellite-induced replication mechanisms"
• "Moreover, such evolutionarily significant hotspots as fragile sites and aphidicolin-induced CNC might resemble many human CNV Overall, we provide the first sound evidence of somatic mosaicism for CNV, with stable variation ratios in different cell types."