Definition of "anaplasia" []

• Reversion of cells to an immature or a less differentiated form, as occurs in most malignant tumors. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "In MB, over-expression of c-MYC has been shown to cause anaplasia and correlate with unfavorable prognosis."