Definition of "allosteric" []

• Of or involving a change in the shape and activity of an enzyme that results from molecular binding with a regulatory substance at a site other than the enzymatically active one. (adjective)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "Under the agreement, Addex will regain rights to intellectual property and know-how and can pursue the program independently. www.addexpharma.com discovers and develops an emerging class of small molecule drugs, called allosteric modulators, which have the potential to be more specific and confer significant therapeutic advantages over conventional "orthosteric" small molecule or biological drugs."
• "In contrast to some of its rivals, Addex has a relatively wide portfolio of new products and a novel technology platform known as allosteric modulation, factors which analysts say make it a potential star of the Swiss biotech sector."
• "The researchers have discovered that apamin binds away from the channel pore, and causes the shape of the channel to change through an 'allosteric' mechanism, resulting in block."