Definition of "agammaglobulinemia" [agammaglobulinemia]

• A congenital or acquired deficiency of gamma globulins in the blood. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "Too little Btk causes a disease called Bruton's agammaglobulinemia, in which the B-lymphocytes fail to mature and produce antibodies, leading to infections."
• "These include, but are not limited to, congenital X-linked agammaglobulinemia, common variable immunodeficiency, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies."
• "But Jack has a rare, genetic immune deficiency disorder - agammaglobulinemia - that makes it difficult for his body to fight off common bacteria and viruses."