Definition of "vinculin" [vinculin]

• A membrane-cytoskeletal protein in focal adhesion plaques, involved in linkage of integrin adhesion molecules to the actin cytoskeleton (noun)

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• "Talin binds vinculin and integrins. talin is a substrate for the Ca2+-activated protease calpain II."
• "Building on earlier studies, Mofrad's team developed a detailed model demonstrating that, when a cell experiences force, focal adhesion proteins such as talin and vinculin change molecular shape."
• "Focal adhesion kinase-dependent regulation of adhesive force involves vinculin recruitment to focal adhesions."