Definition of "hypomethylation" [hypomethylation]

• A decrease in the epigenetic methylation of cytosine and adenosine residues in DNA (noun)

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• "The so-called hypomethylation of the AVP enhancer region was specific to an area of the brain that is intimately involved in stress related hormone release."
• "However, separate analyses in the same study showed that pancreatic cancers with reduced MTHFR function due to loss of an MTHFR allele had more DNA hypomethylation and more chromosomal deletions."
• "Validation studies showed that hypermethylation or hypomethylation of Alu elements in human cell lines could be detected sensitively by the assay after treatment with 5-aza-dC and M. SssI, respectively."