Definition of "hyperphosphorylation" [hyperphosphorylation]

• The state of being fully phosphorylated, so that all potential phosphorylation sites are occupied (noun)

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• "GSK3 adds phosphate to tau protein and "hyperphosphorylation" of tau protein causes it to tangle."
• "The next step will be to identify drug compounds that can negate the effects of the three kinases linked to tau hyperphosphorylation."
• "Of these 26, three of them -- EIF2AK2, DYRK1A and AKAP13 -- were found to cause hyperphosphorylation of tau, permanently dismantling the microtubule bridges."