Definition of "sertraline" [sertraline]

• An oral antidepressant that enhances serotonin activity by inhibiting its uptake by neurons of the central nervous system. (noun)

American Heritage(R) Dictionary of the English Language, Fifth Edition. Copyright (c) 2011 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

• "The generic version of Zoloft, known as sertraline, was the top antidepressant dispensed in 2010 with nearly 36 million prescriptions, and Celexa, or citalopram, was the second-most popular with 32 million prescriptions, according to IMS Health."
• "Seven medications are referenced: sibutramine, orlistat, phentermine, and diethylpropion, and three drugs that are not approved for obesity treatment, fluoxetine, sertraline, and buproprion."
• "Whereas some antidepressants can cause weight gain, fluoxetine and sertraline are both associated with a very modest weight loss just a few pounds."